IJE Advance Access originally published online on December 12, 2007
International Journal of Epidemiology 2008 37(1):173-182; doi:10.1093/ije/dym243
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Intake of ruminant trans fatty acids and risk of coronary heart disease
1Research Unit for Dietary Studies at Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Øster Søgade 18, DK-1357 Copenhagen, Denmark.
2Research Centre for Prevention and Health, Glostrup University Hospital, Nordre Ringvej 57, DK-2600 Glostrup, Denmark.
3Department of Clinical Epidemiology, Aarhus University Hospital, Sdr. Skovvej 15, DK-9100 Aalborg, Denmark.
4Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Sdr. Skovvej 15, DK-9100, Denmark.
5Department of Human Nutrition, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg, Denmark and Capio Diagnostik A/S, Nygårdsvej 32, DK-2100 Copenhagen, Denmark.
*Corresponding author. Department of Clinical Epidemiology, Aarhus University Hospital, Sdr. Skovvej 15, DK-9100 Aalborg, Denmark. E-mail: muj{at}dce.au.dk
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Abstract |
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Background: Studies have shown a positive association between trans fatty acids (TFA) intake and risk of coronary heart disease (CHD), primarily accounted for by industrially produced TFA. Some of these studies indicate an inverse association between ruminant TFA (R-TFA) intake and CHD implying that R-TFA intake is innocuous or even protective against CHD. The aim of this study was to describe the association between R-TFA intake and risk of CHD evaluating both the absolute and the energy-adjusted intake.
Methods: The study was an 18-year follow-up study of 3686 Danes, aged 30–71 years, at baseline without previous CHD.
Results: There were no overall associations between absolute or energy-adjusted R-TFA intakes and risk of CHD. However, among women, indications of inverse associations between R-TFA intake and risk of CHD were found: hazard ratio (HR) per 0.5 g increase in absolute R-TFA intake = 0.84 [95% confidence interval (CI): 0.70, 1.01] and HR per 0.5 g increase in energy-adjusted R-TFA intake = 0.77 (95% CI: 0.55, 1.09). No associations between absolute or energy-adjusted R-TFA intakes and CHD were found among men.
Conclusions: This study suggests that R-TFA intake is not associated with a higher risk of CHD. Whether R-TFA intake is even protective against CHD among women cannot be concluded from this study.
Keywords Coronary disease, dietary fats, intake, ruminant, trans fatty acids
The originally published version of this paper was incorrect. There was an error in the legends of Figure 2 which said "Log HRs were adjusted for the variables listed as model 3 in Table 3" but should be ""...model 3 in Table 4."
Accepted 30 October 2007
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  D. Mozaffarian Commentary: Ruminant trans fatty acids and coronary heart disease--cause for concern? Int. J. Epidemiol., February 1, 2008; 37(1): 182 - 184. [Full Text] [PDF]
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