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IJE Advance Access originally published online on October 5, 2007
International Journal of Epidemiology 2007 36(5):951-957; doi:10.1093/ije/dym193
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.

Colorectal cancer risk, chronic illnesses, operations and medications: case–control results from the Melbourne Colorectal Cancer Study{dagger}

Gabriel A Kune, Susan Kune and Lyndsey F Watson

Department of Surgery, University of Melbourne, Repatriation General Hospital, Heidelberg 3081, Victoria, Australia.


  Abstract

The associations between colorectal cancer risk and several chronic illnesses, operations and various medications were examined in 715 colorectal cancer cases and 727 age- and sex-matched controls in data derived from a large, comprehensive population-based study of this cancer conducted in Melbourne, Australia. There was a statistically significant deficit among cases of hypertension, heart disease, stroke, chronic chest disease and chronic arthritis and a statistically significant excess of ‘haemorrhoids’ among cases, and all of these differences were consistent for both colon and rectal cancers and for both males and females. Although no statistically significant differences were found for other cancers, there were twice as many breast cancers among cases (16) than among controls (8) and also there were 9 uterine cancers among cases and only 2 among controls. There was a statistically significant deficit among cases in the use of aspirin-containing medication and vitamin supplements and this was consistent for both colon and rectal cancers and for both males and females. There was a statistically significant excess of large bowel polypectomy among cases. The modelling of these significant associations simultaneously in a logistic regression equation indicated that hypertension, heart disease, chronic arthritis and aspirin use were each independent effects and consistent for both colon and rectal cancers for both males and females and also that these effects were independent of dietary risk factors previously described in the Melbourne study. The possible relevance of these findings towards an understanding of colorectal cancer risk and aetiology is discussed.

{dagger}First published Cancer Res 1988;48:4399–404. Reprinted with permission.


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