IJE Advance Access originally published online on April 10, 2006
International Journal of Epidemiology 2006 35(4):853-858; doi:10.1093/ije/dyl067
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Special Theme: Intergenerational Influences on Health |
Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (p,p'-DDE) in relation to child growth
1 Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, USA
2 Respiratory and Environmental Health Research Unit, Institut Municipal d'Investigació Mèdica, Barcelona, Spain
3 Department of Health and Human Services, National Center for Environmental Health, Centers for Disease Control and Prevention, USA
4 Department of Health and Human Services, National Institute of Child Health and Human Development, National Institutes of Health, USA
* Corresponding author. Respiratory and Environmental Health Research Unit, Institut Municipal d'Investigació Mèdica. C. Dr. Aiguader, 80. 08003 Barcelona, Spain. E-mail: nribas{at}imim.es
Objective To examine the relation between prenatal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure (a metabolite of the insecticide DDT) and child growth during the first 7 years of life.
Design Prospective cohort study.
Participants 1712 children born between 1959 and 1966 with measured p,p'-DDE concentrations in their mother's serum samples from pregnancy.
Setting Multicenter US Collaborative Perinatal Project (CPP).
Results The highest prenatal concentrations of p,p'-DDE (
60 µg/l), as compared with the lowest (<15 µg/l), were associated with decreased height at age 1 year [adjusted coefficient (SE) = –0.72 cm (0.37), n = 1540], 4 years [–1.14 cm (0.56), n = 1289], and 7 years [–2.19 (0.46), n = 1371]. Among subjects in lower categories of exposure no association was observed.
Conclusions The findings suggest that high prenatal exposure to p,p'-DDE decreases height in children. Impaired growth may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected.
Keywords p,p'-DDE, growth, children, cohort
Accepted 14 March 2006
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