IJE Advance Access originally published online on March 31, 2006
International Journal of Epidemiology 2006 35(4):1025-1033; doi:10.1093/ije/dyl058
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Published by Oxford University Press on behalf of the International Epidemiological Association
Article |
The impact of cardiovascular risk factors on the age-related excess risk of coronary heart disease
Asia Pacific Cohort Studies Collaboration*Correspondence to: Rachel Huxley, Asia Pacific Cohort Studies Collaboration Secretariat, The George Institute for International Health, PO Box M201, Missenden Road, Sydney NSW 2050, Australia. E-mail: rhuxley{at}thegeorgeinstitute.org
Purpose Differences in cardiovascular risk factor levels have been suggested to contribute to the age-related excess risk of coronary heart disease (CHD). The aim of this study was to reliably quantify these contributions using a large prospective dataset.
Methods We carried out an individual participant data meta-analysis of 41 cohort studies (n = 582 134) from Asia, and Australia and New Zealand. Cox models were used to estimate hazard ratios for coronary death, comparing individuals aged 55–64, 65–74, and 
5 yrs with those aged <55 yrs. Adjustments were made for coronary risk factors to quantify their contributions to the age differential.
Results During 4.1 million person-years of follow-up, there were 2915 deaths from CHD. The risk of CHD increased substantially with age in all groups, especially in women. Differences in cardiovascular risk factors explained between one-quarter to one-third of the age-related excess of CHD in men and one-half of that in women. Systolic blood pressure was the chief contributor to the excess risk in all groups.
Conclusions Systolic blood pressure was the most important modifiable risk factor contributing to the excess CHD risk that occurs with aging in men and women, but in comparison with the effects of age itself, the effects of blood pressure are small.
Keywords Aging, cardiovascular risk factors, CHD, sex
Accepted 10 March 2006
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Walter Interrelationships Among HDL Metabolism, Aging, and Atherosclerosis Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1244 - 1250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Timpson, R. Harbord, G. Davey Smith, J. Zacho, A. Tybjaerg-Hansen, and B. G. Nordestgaard Does Greater Adiposity Increase Blood Pressure and Hypertension Risk?: Mendelian Randomization Using the FTO/MC4R Genotype Hypertension, July 1, 2009; 54(1): 84 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sasayama Heart Disease in Asia Circulation, December 16, 2008; 118(25): 2669 - 2671. [Full Text] [PDF]
|
|
|
|
|
|
K. J. Meyers, T. H. Mosley, E. Fox, E. Boerwinkle, D. K. Arnett, R. B. Devereux, and S. L.R. Kardia Genetic Variations Associated With Echocardiographic Left Ventricular Traits in Hypertensive Blacks Hypertension, May 1, 2007; 49(5): 992 - 999. [Abstract] [Full Text] [PDF]
|
|