IJE Advance Access originally published online on May 26, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
International Journal of Epidemiology, Volume 33, Number 3, pp. 596-602
IJE vol.33 no.3 © International Epidemiological Association 2004; all rights reserved.
Article |
Tubal sterilization and risk of ovarian, endometrial and cervical cancer. A Danish population-based follow-up study of more than 65 000 sterilized women
1 Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Correspondence: Susanne K Kjaer, Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100, Copenhagen Ø, Denmark. E-mail: susanne{at}cancer.dk
Background On the basis of a population-based cohort, we assessed the cancer risk, focusing on gynaecological cancers and pre-malignant lesions, among women with a previous tubal sterilization.
Methods Using the Danish Hospital Discharge Register we identified 65 232 women who had a tubal sterilization (1977–1993). The cohort was followed for cancer occurrence, and compared with the expected number based on the national cancer incidence rates.
Results The overall risk of ovarian cancer was decreased (standardized incidence ratio [SIR] = 0.82; 95% CI: 0.6, 1.0), and it was still decreased 
10 years after the sterilization (SIR = 0.65; 95% CI: 0.4, 1.0). The rate of endometrial cancer was also decreased (SIR = 0.66; 95% CI: 0.5, 1.0), the risk continued being moderately reduced during follow-up, although it was not statistically significant.
Conclusions In this nationwide, population-based study we find that women with tubal sterilization have a decreased risk of subsequent development of ovarian cancer. As the protective effect is not decreasing with years of follow-up, our data do not support that ‘screening’ bias can explain the protective effect, but indicate that the sterilization itself may convey a reduction in risk. The same pattern is found for endometrial cancer, the association being less strong.
Keywords Tubal sterilization, cohort study, risk, gynaecological cancer
Accepted 6 October 2003
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Reid, A. Segal, J. S. Heyworth, N. H. de Klerk, and A. W. Musk Gynecologic and Breast Cancers in Women After Exposure to Blue Asbestos at Wittenoom Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 140 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Abenhaim, L. Titus-Ernstoff, and D. W. Cramer Ovarian cancer risk in relation to medical visits, pelvic examinations and type of health care provider Can. Med. Assoc. J., March 27, 2007; 176(7): 941 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Terry, L. Titus-Ernstoff, J. R. McKolanis, W. R. Welch, O. J. Finn, and D. W. Cramer Incessant Ovulation, Mucin 1 Immunity, and Risk for Ovarian Cancer Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 30 - 35. [Abstract] [Full Text] [PDF]
|
|