International Journal of Epidemiology 2003;32:579-583
© International Epidemiological Association 2003
Cancer |
Aggregation of stomach cancer history in parents and offspring in comparison with other sites
1 Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
2 Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan.
3 Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Japan.
4 Department of Public Health, Wakayama Medical University, Wakayama, Japan.
5 Department of Public Health, Showa University School of Medicine, Tokyo, Japan.
6 Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
7 Department of Clinical Epidemiology, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Kitakyushu, Japan.
8 Japan Collaborative Cohort Study for Evaluation of Cancer Risk.
Correspondence: Takaaki Kondo, Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. E-mail: taka-ngy{at}umin.ac.jp
Background The aim of this study is to evaluate the magnitude of the aggregation of a stomach cancer history in parents and their offspring in comparison with that of a history at other sites.
Methods We used the baseline data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study), which was initiated during 1988–1990 in Japan. Association of the cancer history of the subjects’ parents with that of the subjects themselves and any of the subjects’ siblings was evaluated with odds ratios (OR) by the crude and generalized estimating equations (GEE) technique for four sites: stomach, colorectum, liver, and lung/bronchus.
Results The aggregation of a history of stomach cancer between parents and their offspring was evident with significant OR >2.5. The magnitude of the parent–offspring association of a disease history of the colorectum and liver was found to be greater than that for stomach cancer. Conversely, lung and bronchus cancer failed to demonstrate a significant aggregation.
Conclusions The hereditary and environmental influences shared by parents and offspring are likely to play a strong aetiological role in colorectal or liver cancer versus a weaker but still significant role in stomach cancer. In contrast, the aetiological role of familial predisposition to lung cancer was indeterminate, which suggests a predominant role of non-familial factors in the development of lung cancer.
Keywords Familial aggregation, generalized estimating equation, parents and offspring, odds ratio
Accepted 13 February 2003
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