International Journal of Epidemiology 2003;32:234-239
© International Epidemiological Association 2003
Special Theme: Cancer |
Dietary fibre and risk of colorectal cancer in the Breast Cancer Detection Demonstration Project (BCDDP) follow-up cohort
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Correspondence: Volker Mai, Division of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, 10 South Pine St, MSTF-934, Baltimore, MD 21201, USA. E-mail: vmai{at}epi.umaryland.edu
Background The hypothesis that increased intake of dietary fibre lowers the risk of colorectal cancer (CRC) has recently been weakened by results from cohort and intervention studies that did not detect such an association. We investigated the association between dietary fibre intake and risk of CRC in a cohort of women that prospectively answered a food frequency questionnaire (FFQ).
Methods We studied 45 491 women in the Breast Cancer Detection Demonstration Project (BCDDP) follow-up cohort. A 62-item FFQ was administered from 1987 and 1989 to assess dietary intake. Participants received follow-up questionnaires (in 1992–1995 and 1995–1998) on which they reported incident cancers. Cases were also identified through searches of the National Death Index and state cancer registries. Cox proportional hazard regression was used to generate risk ratios and 95% CI for quintiles of total fibre intake and fibre subtypes.
Results During a mean follow-up time of 8.5 years we identified 487 colorectal cancer cases. The 10th and 90th percentiles of dietary fibre intake were 5.4 g and 18.2 g respectively. For total fibre we observed no association with colorectal cancer (fifth versus first quintile, RR = 0.94, 95% CI: 0.71–1.23). Analyses by subgroup of fibre and by anatomical subsite did not reveal any stronger inverse associations.
Conclusions Within a cohort of older women characterized by a relatively low fibre intake, there was little evidence that dietary fibre intake lowers the risk of colorectal cancer.
Keywords Cancer, cohort, colon, dietary fibre, nutrition, rectum
Accepted 13 September 2002
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Ryan-Harshman and W. Aldoori Diet and colorectal cancer: Review of the evidence Can Fam Physician, November 1, 2007; 53(11): 1913 - 1920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schatzkin, T. Mouw, Y. Park, A. F Subar, V. Kipnis, A. Hollenbeck, M. F Leitzmann, and F. E Thompson Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health Study Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1353 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Wakai, C. Date, M. Fukui, K. Tamakoshi, Y. Watanabe, N. Hayakawa, M. Kojima, M. Kawado, K. Suzuki, S. Hashimoto, et al. Dietary Fiber and Risk of Colorectal Cancer in the Japan Collaborative Cohort Study Cancer Epidemiol. Biomarkers Prev., April 1, 2007; 16(4): 668 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T Jacobs, E. Lanza, D. S Alberts, C.-H. Hsu, R. Jiang, A. Schatzkin, P. A Thompson, and M. E. Martinez Fiber, sex, and colorectal adenoma: results of a pooled analysis Am. J. Clinical Nutrition, February 1, 2006; 83(2): 343 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Park, D. J. Hunter, D. Spiegelman, L. Bergkvist, F. Berrino, P. A. van den Brandt, J. E. Buring, G. A. Colditz, J. L. Freudenheim, C. S. Fuchs, et al. Dietary Fiber Intake and Risk of Colorectal Cancer: A Pooled Analysis of Prospective Cohort Studies JAMA, December 14, 2005; 294(22): 2849 - 2857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Michels, C. S. Fuchs, E. Giovannucci, G. A. Colditz, D. J. Hunter, M. J. Stampfer, and W. C. Willett Fiber Intake and Incidence of Colorectal Cancer among 76,947 Women and 47,279 Men Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 842 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Papas, E. Giovannucci, and E. A. Platz Fiber from Fruit and Colorectal Neoplasia Cancer Epidemiol. Biomarkers Prev., August 1, 2004; 13(8): 1267 - 1270. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Lam and G. Leung Geoethnic-sensitive and cross-culture collaborative epidemiological studies Int. J. Epidemiol., April 1, 2003; 32(2): 178 - 180. [Full Text] [PDF]
|
|
|
|
|
|
D. A Lawlor and A. R Ness Commentary: The rough world of nutritional epidemiology: Does dietary fibre prevent large bowel cancer? Int. J. Epidemiol., April 1, 2003; 32(2): 239 - 243. [Full Text] [PDF]
|
|