International Journal of Epidemiology 2001;30:400-402
© International Epidemiological Association 2001
Brief Report |
The genetics of signal transduction and the effect of smoking on intrauterine growth
a Chair of Preventive and Social Pediatrics, University of Rome, Tor Vergata, School of Medicine, Rome, Italy.
b Department of Pediatrics, St. Massimo Hospital, USSL, Penne, Italy.
c Laboratory of Genetics, University of Camerino, School of Science, Camerino, Italy.
Correspondence: Prof. Egidio Bottini, Dipartimento di Biopatologia e Diagnostica per Immagini, Facoltà di Medicina, Via della Ricerca Scientifica, nsc, Roma, Italy. E-mail: bottini{at}med.uniroma2.it
Abstract
We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples point to a protective role of maternal ACP1 genotypes with medium-high activity against intrauterine growth retardation caused by smoking.
Keywords cLMWPTP, ACP1, smoke, birthweight
Accepted 28 November 2000
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