International Journal of Epidemiology 2001;30:353-362
© International Epidemiological Association 2001
Cancer |
Are coffee and tea consumption associated with urinary tract cancer risk? A systematic review and meta-analysis
a Department of Epidemiology, and
b Department of Methodology and Statistics, Maastricht University, Maastricht, The Netherlands.
c Department of Epidemiology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
Correspondence: MPA Zeegers, Maastricht University, Department of Epidemiology, PO Box 616, 6200 MD Maastricht, The Netherlands. E-mail:mpa.zeegers{at}epid.unimaas.nl
Abstract
Background Narrative reviews have concluded that there is a small association between coffee consumption and an increased risk of urinary tract cancer, possibly due to confounding by smoking. No association for tea consumption has been indicated. This systematic review attempts to summarize and quantify these associations both unadjusted and adjusted for age, smoking and sex.
Method Thirty-four case-control and three follow-up studies were included in this systematic review. Summary odds ratios (OR) were calculated by meta-regression analyses.
Results The unadjusted summary OR indicated a small increased risk of urinary tract cancer for current coffee consumers versus non-drinkers. The adjusted summary OR were: 1.26 (95% CI : 1.09–1.46) for studies with only men, 1.08 (95% CI : 0.79–1.46) for studies with only women and 1.18 (95% CI : 1.01–1.38) for studies with men and women combined. Neither unadjusted nor adjusted summary OR provided evidence for a positive association between tea consumption and urinary tract cancer. Even though studies differed in methodology, the results were rather consistent. We did not perform dose-response analyses for coffee and tea consumption due to sparse data.
Conclusions In accordance with earlier reviews, we found that coffee consumption increases the risk of urinary tract cancer by approximately 20%. The consumption of tea seems not to be related to an increased risk of urinary tract cancer.
Keywords Coffee, tea, urological neoplasms, bladder neoplasms, meta-analysis, epidemiology
Accepted 12 October 2000
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