International Journal of Epidemiology 2000;29:573-578
© International Epidemiological Association 2000
Predictive value of the HIV paediatric classification system for the long-term course of perinatally infected children
a Department of Paediatrics, University of Florence, Florence, Italy.
b Department of Paediatrics, University of Turin, Turin, Italy.
c Epidemiology Unit, Centre for the Study and Prevention of Cancer, Careggi Hospital, Florence, Italy.
Reprint requests to: Prof. Maurizio de Martino, Coordinator of the Italian Register for HIV Infection in Children, Department of Paediatrics, University of Florence, Via Luca Giordano 13, I-50132 Florence, Italy. E-mail: mdm{at}ao-meyer.toscana.it
Background To compare the Centers for Disease Control and Prevention (CDC) paediatric classification system with the long-term course of perinatal human immunodeficiency virus type 1 (HIV-1) infection.
Methods Prospective study on 366 perinatally infected children followed-up from birth and checked at least every 2 months. Survival, smoothed hazard, adjusted hazard ratio of death, and transition probabilities in clinical and immunological categories were outcome measures.
Results Survival was 49% (95% CI : 40–58%) at 8 years. The risk of death was high before the age of 2, relatively low between ages 2 and 7, and contained thereafter. Children did not advance through the categories sequentially. Survival at 8 years was 61.7% (95% CI : 49.8–73.6%) in those children who had passed through clinical category A; the hazard ratio of death was 2.5 (95% CI : 1.7–3.8) for 175 (47.9%) children who skipped this category. Transition probability in clinical category B was 39.9% (95% CI : 32.3–45.6%) after one year, but 59.1% (95% CI : 51.4–66.8%) after 5 years. Before 2 years of age, the probability of entry into category C (40%; 95% CI : 35–45%) was higher than that of entry into immunological category 3 (28%; 95% CI : 22–34%).
Conclusions The classification system stands comparison with the clinical reality, but the CD4-positive cell thresholds in infancy should be adjusted and category B indicator diseases better distributed to improve their predictive value.
Keywords CD4-positive lymphocytes, CDC paediatric classification system, disease progression, perinatal HIV-1 infection, survival
Accepted 27 October 1999
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