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© 1998 Oxford University Press

research-article

Incidence of acquired immunodeficiency syndrome (AIDS)-related Kaposi's sarcoma in the Aquitaine Cohort, France, 1988–1996

Michel Dupona, Catherine Marimoutoua,b,, Céline Cazorlaa, Christine Binquetb, Geneviève Chêneb, Jean-Luc Pellegrina, Hervé Dutronca, Caroline Noutsa, François Dabisb and Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA)a,b

aCentre d'Information et de Soins de l'Immunodéfidence Humaine (CISIH), Centre Hospitalier Universitaire (CHU) Bordeaux, France
bUnité INSERM 330, Université Victor Segalen Bordeaux 2

Reprint requests to: Dr C Marimoutou, Unité INSERM n°330, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France

OBJECTIVE: To assess secular trends of the incidence of Kaposi's sarcoma (KS) between 1988 and 1996 in the Aquitaine Cohort of human immunodeficiency virus type 1 (HIV 1)-infected subjects (southwestern France).

METHODS: Adults of both sexes of all HIV-transmission categories were included. We distinguished between incident and prevalent KS and in case of multiple acquired immunodeficiency syndrome (AIDS) defining illnesses between initial or subsequent KS. Only incident KS were considered for annual incidence rate calculation.

RESULTS: Overall, 21.2% (356/1678) of homosexuals and 1.9% (58/3030) of the other patients were diagnosed with KS over time. Although there was a sharp decrease in 1996 for initial KS, the annual incidence rate of KS was stable over time in the overall cohort as well as in homosexuals (4.3% per year on the average for KS as an initial AIDS-defining illness and 2.1% per year for subsequent KS in homosexuals). The median CD4+ cell count at the time of diagnosis of KS was 56 per mm3 (78 for initial KS, 14 for subsequent KS), with no significant variation over time.

CONCLUSIONS: In the Aquitaine Cohort, the annual incidence of KS has remained stable between 1988 and 1995 with a recent decline in 1996, only for initial KS, while case management of HIV-infected subjects changed drastically.

Keywords Kaposi's sarcoma, incidence, HIV infection, AIDS, cohort, secular trends

Accepted 9 April 1998


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