© 1998 Oxford University Press
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Relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ
a Nlshigoken-cho 8-8-607, Shlnjuku, Tokyo 1, 620812. Japan
bDepartment of Public Health, Tokyo University School of Medicine Tokyo, Japan
cPL Tokyo Health Care Center Tokyo, Japan
dDepartment of Public Health. Kyushu University School of Medicine Fukuoka, Japan
BACKGROUND: No one has previously examined the relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ.
METHODS: A case-control study was performed with 129 cases of colorectal carcinoma in situ and 258 matched controls among examinees undergoing a health check-up in Tokyo from January 1991 to March 1993.
RESULTS: There was a significant, positive association between serum total cholesterol levels and the risk of colorectal carcinoma in situ after adjustment for age, sex, body mass index, smoking status and alcohol consumption. Serum triglyceride levels were significantly and positively associated with colorectal carcinoma in situ risk regardless of adjustment for the above covariates. Although there was no clear relation between colorectal carcinoma in situ and fasting plasma glucose levels, a modest increase of colorectal carcinoma in situ risk was observed in the highest category (
116 mg/dl) of fasting plasma glucose levels.
CONCLUSIONS: The findings suggest a positive association between serum total cholesterol levels and the risk of colorectal cancer, rather than an inverse relation. The strong association with serum triglyceride levels and the weak association with fasting plasma glucose levels support the hypothesis that hyperinsulinaernia may play an important role in colorectal carcinogenesis.
Keywords Colorectal cancer, carcinoma in situ, serum triglycerides, serum total cholesterol, fasting plasma glucose, hyperinsulinaemia
Accepted 22 December 1997
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