© 1998 Oxford University Press
research-article |
Pre-natal and early life risk factors for childhood onset diabetes mellitus: a record linkage study
aEpidemiological Monitonng Unit, London School of Hygiene & Tropical Medicine, University of London Keppel Street, London WCIE 7HT, UK
bUnit of Health-Care Epidemiology, Department of Public Health and Primary Care, University of Oxford Oxford, UK
BACKGROUND: Using data from the Oxford Record Linkage Study (ORLS) we conducted a case- control study to examine pre-natal and early life risk factors for childhood and adolescent onset diabetes mellitus.
METHODS: We identified 160 boys and 155 girls born 1965–1986 and admitted to hospital with a diagnosis of diabetes during 1965–1987 in the ORLS area. Up to eight controls were matched to each case on sex, year of birth and hospital or place of birth. We linked the hospital records for each child to all of that child's hospital records and to his or her mother's maternity record.
RESULTS: There were no significant associations between subsequent diabetes and birthweight, gestational age, birthweight for gestational age, maternal age and parity. There were increased risks with not breastfeeding (relative risk [RR] = 1.33; 95% CI: 0.76–2.34), and with diabetes recorded in the mother during pregnancy (RR – 5.87; 95% CI: 0.90%38.3), but these were not statistically significant. There was a significantly raised risk with pre-eclampsia or eclampsia during pregnancy (RR = 1.48; 95% CI: 1.05–2.10).
CONCLUSIONS: Pre-eclampsia may be the result of an immunogenetic incompatibility between mother and fetus, and this early immunological disturbance might be related to incidence of diabetes in later life.
Keywords Insulin dependent diabetes mellitus, pre-natal risk factors, case-control study, medical record linkage
Accepted 28 October 1997
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Harder, K. Roepke, N. Diller, Y. Stechling, J. W. Dudenhausen, and A. Plagemann Birth Weight, Early Weight Gain, and Subsequent Risk of Type 1 Diabetes: Systematic Review and Meta-Analysis Am. J. Epidemiol., June 15, 2009; 169(12): 1428 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Chung, G. Raman, T. Trikalinos, J. Lau, and S. Ip Interventions in Primary Care to Promote Breastfeeding: An Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med, October 21, 2008; 149(8): 565 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M Virtanen and M. Knip Nutritional risk predictors of {beta} cell autoimmunity and type 1 diabetes at a young age Am. J. Clinical Nutrition, December 1, 2003; 78(6): 1053 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Rapid Early Growth Is Associated With Increased Risk of Childhood Type 1 Diabetes in Various European Populations Diabetes Care, October 1, 2002; 25(10): 1755 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C Stene, P. Magnus, R. T Lie, O. Sovik, G. Joner, and the Norwegian Childhood Diabetes Study Group Maternal and paternal age at delivery, birth order, and risk of childhood onset type 1 diabetes: population based cohort study BMJ, August 18, 2001; 323(7309): 369 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C Stene, P. Magnus, R. T Lie, O. Søvik, G. Joner, and The Norwegian Childhood Diabetes Study Group Birth weight and childhood onset type 1 diabetes: population based cohort study BMJ, April 14, 2001; 322(7291): 889 - 892. [Abstract] [Full Text]
|
|