© 1998 Oxford University Press
research-article |
Prevalence and correlates of herpes simplex virus type 2 infection: evaluation of behavioural risk factors
aDepartment for Infectious Diseases Epidemiology, National Institute of Public Health and the Environment P0 Box 1, 3720 BA Bilthoven, The Netherlands
bVirus Reference Division, Central Public Health Laboratory London, UK
cDept of Public Health and Environment, Municipal Health Service Amsterdam, The Netherlands
dResearch Laboratory for Infectious Diseases, National institute of Public, Health and the Environment Bilthoven, The Netherlands
OBJECTIVE: To examine the prevalence and correlates of infection with herpes simplex virus type 2 (HSV-2) among sexually transmitted disease (STD) clinic attenders, we studiedthe prevalence of antibodies to HSV-2 and their association with risk behaviour.
METHODS: Data were collected in a cross-sectional study among STD clinic attenders in Amsterdam. Seropositivity for HSV-2 was determined in 1798 serum samples by means of a monoclonal antibody-blocking enzyme-linked imlnunoassay.
RESULTS: The prevalence of HSV-2 antibodies was higher than expected: 32.3% in a population in which 3% had current genital herpes and 8% gave a history of genital herpes. Of those with HSV-2 antibodies, only 18% had a history of genital herpes. A strong independent association with the presence of HSV-2 antibodies was found for sexual behaviour, more specifically: homosexual orientation, increasing number of years of sexual activity, increasing number of lifetime partners, number of past gonococcal infections, having receptive anal and (or) vaginal contact.
CONCLUSION: The presence of HSV-2 antibodies had a strong association with past sexual behaviour and, [or both sexes, with receptive anal intercourse. HSV-2 antibodies may be used as a surrogate marker of sexual risk behaviour in comparing different populations over time.
Keywords Herpes genitalis, seroprevalence, epidemiology, risk factors, sexual behaviour, sexually transmitted diseases
Accepted 27 June 1997
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