International Journal of Epidemiology, Vol 26, 830-836, Copyright © 1997 by International Epidemiological Association
JV Metcalf, RS Bhopal, J Gray, D Howel and OF James
OBJECTIVE: To describe the incidence and prevalence of primary biliary
cirrhosis in an urban population between 1987 and 1994, using stringent
inclusion criteria and a well-defined study area and population. DESIGN:
Descriptive study based on a case register compiled by a retrospective and
prospective case-finding exercise and examination of case notes. SETTING:
The city of Newcastle upon Tyne. MAIN INCLUSION CRITERIA: (1) Definite
cases: fulfilling all three of the following diagnostic criteria: positive
antimitochondrial antibody (AMA) > or = 1:40; cholestatic liver function
tests (LFT); diagnostic or compatible liver histology. (2) Probable cases:
fulfilling two of these criteria. SUBJECTS: All cases of primary biliary
cirrhosis identified by multiple case-finding methods, alive from 1 January
1987 to 31 December 1994, in the defined area. MAIN OUTCOME MEASUREMENTS:
Incidence and point prevalence rates by age and sex. RESULTS: In all, 202
potential cases were identified, of whom 160 met at least two inclusion
criteria. In definite cases annual incidence varied from 14 to 32 (mean 22)
per million whole population (with no clear trend) and point prevalence
rose from 180 per million in 1987 to 240 in 1994. Mean age at diagnosis in
cases incident during the study period was 63.2 years (S.D. 11.1 years,
range 39.8-85.7 years). CONCLUSIONS: Primary biliary cirrhosis is much more
common in Newcastle than has previously been reported anywhere in the
world, and prevalence appears to be rising.
ARTICLES
Incidence and prevalence of primary biliary cirrhosis in the city of Newcastle upon Tyne, England
Department of Medicine, Medical School, University of Newcastle upon Tyne, UK.
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