International Journal of Epidemiology, Vol 26, 730-738, Copyright © 1997 by International Epidemiological Association
JD Kark, M Leinonen, O Paltiel and P Saikku
BACKGROUND: A number of studies in European and North American populations
have reported associations between Chlamydia pneumoniae seropositivity and
coronary heart disease (CHD). Our objective was to assess the association
of IgG and IgA antibodies to C. pneumoniae with acute myocardial infarction
(MI) in a population-based case-control study in a Middle Eastern country.
METHODS: Eligible cases aged 25-64 with a first acute MI were ascertained
through an active surveillance system in Jerusalem hospitals between 1987
and 1989 (85% response). Controls were Jerusalem residents aged 25-64
sampled from the national population registry (83% response). Data on
sociodemographic variables, CHD history and risk factors were collected by
interview. Chlamydia serology, available for 93% of eligible participants,
was performed by microimmunofluorescence on frozen stored samples using the
TWAR antigen. Altogether, 251 male and 51 female cases, and 324 male and
162 female controls were analysed. RESULTS: Overall, high IgG titres (>
or = 128) were not associated with increased risk of acute MI (Odds ratio
[OR] = 0.74 for men [95% confidence interval (CI): 0.47-1.17] and 0.91 for
women [95% CI: 0.43-1.94]); neither were high IgA titres (> or = 80) (OR
= 1.11 for men [95% CI: 0.71-1.73] and 1.15 for women [95% CI: 0.33-4.0]).
At IgG and IgA titres of > 32 and > 20 respectively there was also no
relation. CONCLUSIONS: An association of C. pneumoniae seropositivity with
acute MI was not confirmed in this population with a very high IgG
seropositivity prevalence of 84% in males and 69% in females. However, we
cannot exclude the possibility that a postulated recent outbreak obscured
an association with chronic C. pneumoniae infection.
ARTICLES
Chlamydia pneumoniae and acute myocardial infarction in Jerusalem
Epidemiology Unit, Hadassah Medical Organization, Jerusalem, Israel.
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