Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Genton, B
Right arrow Articles by Mokela, D
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Genton, B
Right arrow Articles by Mokela, D
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Journal of Epidemiology, Vol 26, 670-676, Copyright © 1997 by International Epidemiological Association

ARTICLES

Indicators of fatal outcome in paediatric cerebral malaria: a study of 134 comatose Papua New Guinean children

B Genton, F al-Yaman, MP Alpers and D Mokela
Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea.

BACKGROUND: No comprehensive data on the clinical features and the prognosis of cerebral malaria in the South Pacific are available at present. We conducted a prospective study in children with cerebral malaria to assess the case fatality rate (CFR) in the region and to identify potential risk factors for death. METHODS: We recruited 134 children admitted to the Madang General Hospital between April 1991 and October 1993 with a strictly defined diagnosis of cerebral malaria. Besides clinical examination, we collected a blood sample for parasitological haematological and biochemical assessment. RESULTS: The CFR was 11.9% and the prevalence of residual neurological sequelae at discharge was 1.5%. The proportion of children presenting with deep coma (12%) or hypoglycaemia (17%) was lower in our study than in African ones, where severe complications are more frequent. Also mortality associated with hypoglycaemia on admission was lower. Clinical or laboratory conditions significantly associated with death were deep coma, malarial anaemia and hyperleucocytosis. CONCLUSIONS: All conditions associated with deep coma, such as shock, hypoglycaemia and acidosis, should be corrected. Also prompt administration of blood transfusions to patients with anaemia is likely to reduce the occurrence of death in Papua New Guinean children with cerebral malaria.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
F. P. MOCKENHAUPT, S. EHRHARDT, J. BURKHARDT, S. Y. BOSOMTWE, S. LARYEA, S. D. ANEMANA, R. N. OTCHWEMAH, J. P. CRAMER, E. DIETZ, S. GELLERT, et al.
MANIFESTATION AND OUTCOME OF SEVERE MALARIA IN CHILDREN IN NORTHERN GHANA
Am J Trop Med Hyg, August 1, 2004; 71(2): 167 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
N. A. Beare, C. Southern, C. Chalira, T. E. Taylor, M. E. Molyneux, and S. P. Harding
Prognostic Significance and Course of Retinopathy in Children With Severe Malaria
Arch Ophthalmol, August 1, 2004; 122(8): 1141 - 1147.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.