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International Journal of Epidemiology, Vol 26, 288-296, Copyright © 1997 by International Epidemiological Association
Y Li, J Stamler, Z Xiao, A Folsom, S Tao and H Zhang
BACKGROUND: Reports on serum uric acid (SUA) levels in Chinese populations
are sparse, but there is evidence that hyperuricaemia and gout are not
uncommon. This paper characterizes SUA levels, their correlates, and their
relationship to blood pressure (BP) and prevalent high blood pressure (HBP)
for urban and rural adult population samples in north China. METHODS: In
1987-1988, a cross-sectional study was carried out, using standardized
methods, on men and women aged 40.58 in a Beijing area urban steel mill (N
= 2013) and on rural farms (1507). Main outcome measures were SUA, systolic
and diastolic blood pressure (SBP, DBP), and prevalent HBP (SBP > or =
140 or DBP > or = 90 mmHg or receiving an antihypertensive drug).
RESULTS: Mean SUA levels for men were 5.75 mg/dl in urban and 5.58 mg/dl in
rural settings; for women, 4.67 and 4.48 mg/dl. Mean values were higher
with age in women, but not in men. Age-standardized prevalence rates of HBP
were significantly higher in upper SUA strata (men > or = 7.00, women
> or = 6.00 mg/dl) than lower SUA strata both with and without inclusion
of those on antihypertensive drugs. Mean SUA levels were correspondingly
higher in hypertensive than non-hypertensive people. In multiple regression
analyses, body mass index and serum triglycerides were strongly associated
with SUA. Also SBP, DBP, and HBP were generally associated with SUA for the
whole population sample, with smaller coefficients after excluding those on
antihypertensive drugs. However, in these multivariate analyses the
strength of the association was low order. CONCLUSION: In addition to its
strong association with body mass index, SUA is independently related to
serum lipids, particularly triglycerides, and to serum glucose. While some
of the univariate relation of SUA to BP is apparently due to the strong
relation of body mass to both SUA and BP, a low order significant relation
between SUA and BP remains with control for BMI.
ARTICLES
Serum uric acid and its correlates in Chinese adult populations, urban and rural, of Beijing. The PRC-USA Collaborative Study in Cardiovascular and Cardiopulmonary Epidemiology
Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Beijing, PRC.
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