International Journal of Epidemiology, Vol 26, 92-99, Copyright © 1997 by International Epidemiological Association
FH Steffensen, HT Sorensen, A Brock, H Vilstrup and T Lauritzen
BACKGROUND: Based on the increased consumption of alcohol in Denmark the
aim of this study was to measure prevalence of abnormal liver- derived
enzymes in a homogeneous Danish population and possible associations with
alcohol consumption, smoking and body mass index (BMI). METHOD: In a
representative population sample of 905 people (aged 30-50) from the
baseline survey of the Ebeltoft Health Promotion Project in Denmark, we
examined prevalence of abnormal liver-derived enzymes and its possible
association with self-reported alcohol consumption, smoking and BMI,
applying logistic regression analyses. RESULTS: In a significant
proportion, 12% (women 8%; men 16%) of the cohort we found raised levels of
liver-derived enzymes associated with moderate self-reported alcohol intake
adjusted for BMI and smoking. If the intake was higher than moderate, i.e.
> 28 units per week (one unit equals 12 g of alcohol), the odds ratio
(OR) for raised liver enzymes increased further;
S-gamma-glutamyltransferase (GGT) (OR: for women 24.4; men 18.4).
S-aspartate-aminotransferase (ASAT) (24.2; 5.8) and S-
alanine-aminotransferase (ALAT) (27.2; 3.0). Furthermore, daily smoking
increased the risk of raised liver enzymes in women (OR: 3.4-4.2), and
obesity (BMI > or = 30 kg/m2) in men showed a positive association with
all three enzymes (OR: 3.0-9.0). CONCLUSIONS: The occurrence of raised
liver-derived enzymes was frequent in the Danish population sample and
associated with moderate self-reported alcohol consumption adjusted for BMI
and smoking.
ARTICLES
Alcohol consumption and serum liver-derived enzymes in a Danish population aged 30-50 years
Danish Epidemiology Science Centre, University of Aarhus, Denmark.
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