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© 1996 Oxford University Press

research-article

Association between Serum Sialic Acid Concentration and Carotid Atherosclerosis Measured by B-Mode Ultrasound

LENNART RÅSTAM*,**,, GUNNAR LINDBERG{dagger}, AARON R FOLSOM*, GREGORY L BURKE{ddagger}, PETER NILSSON-EHLE§ and ARNE LUNDBLAD||

*Division of Epidemiology, School of Public Health, University of Minnesota Minneapolis, USA.
**Department of Coomunity Health Sciences, Lund University Malmö, Sweden.
{dagger}The NEPI Foundation Malmö, Sweden.
{ddagger}Department of Public Health Sciences, Bowman Gray School of Medicine Winston-Salem, USA.
§Department of Clinical Chemistry, Lund University Lund, Sweden.
||Department of Clinical Chemistry, University of Linköping Linköping, Sweden.

Reprint requests to: Dr Lennart Råstam, Department of Community Health Sciences, Lund University, Malmo General Hospital, S-20502 Malmo, Sweden.

Råstam L (Department of Community Health Sciences, Malmo General Hospital, S-20502 Malmo, Sweden), Lindberg G, Folsom A R, Burke G L, Nilsson-Ehle P, Lundblad A for the ARIC investigators. Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. International Journal of Epidemiology 1996; 25: 953–958

BACKGROUND: Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atheroscierosis was evaluated.

METHODS: From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-media wall thickness above the 90th percentile (measured with B-mode ultrasound) were matched 1: 1 with controls without atherosclerosis. Serum sialic acid, plasma LDL and HDL cholesterol, serum insulin concentrations, blood pressure, antihypertensive medication use, and smoking status were used to assess the Independent contribution of the sialic acid level to carotid atherosclerosis.

RESULTS: The mean (SD) serum sialic acid concentration was 75.0 (9.7) mg/dl in cases and 70.7 (8.9) mg/dl in controls (P = 0.0001). In a conditional logistic model with adjustment for age, LDL-cholesterol, HDL-cholesterol, serum insulin, smoking and hypertension, the odds ratio associated with sialic acid above the 75th percentile (≥78.3 mg/dl) versus below was 1.65 with a 95% confidence interval of 1.01–2.70.

CONCLUSION: The sialic acid level is correlated with the presence of carotid atherosclerosis, independently of major cardiovascular disease risk factors. The biological mechanism behind this association is not resolved.

Keywords atherosclerosis, B-mode ultrasound, glycoproteins, sialic acid

Revised 1 March 1996


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