© 1996 Oxford University Press
research-article |
Hepatitis B and C Virus, Clonorchis sinensis for the Risk of Liver Cancer: A Case-Control Study in Pusan, Korea
*Department of Preventive Medicine. College of Medicine, Dong-A University #1 3Ga Dongdaeshin-dong, So-gu Pusan, Korea 602-103.
**Department of Preventive Medicine Pusan, Korea.
Department of Internal Medicine, College of Medicine, Inje University Pusan, Korea.
Department of Preventive Medicine, College of Medicine, Seoul National University Seoul, Korea.
Department of Public Health, School of Medicine, Fukuoka University Fukuoka, Japan.
Shin H-R (Department of Preventive Medicine, College of Medicine, Dong-A University, #1 3Ga Dangdaeshin-dong, So-gu Pusan, Korea 602-103), Lee C-U, Park H-J, Seol S-Y, Chung J-M, Chol H-C, Y-O and Shigemaslu T. International Journal Epidemiology 1996; 25: 933–940.
BACKGROUND: Liver cancer mortality in Korea is the highest in the world. Hepatitis B and C viruses (HBV, HCV) are known to be the major risk factors of hepatocellular carcinoma (HCC). Cholangiocarcinoma (CLG) accounts for more than 20% of liver cancer in the Pusan area. In Korea, the diferent roles of known risk factors in the development of HCC or CLG have not been adequately evaluated.
METHODS: Case-control studies involved 203 incident HCC cases. 406 controls matched to the HCC cases for age (±4years) and sex, and 41 CLG cases (the HCC controls were used). They were carried out from August 1990 to August 1993.
RESULTS: Relative risk (RR) of HBsAg (87.4; 95% confidence interval (Cl): 22.2–344.3) and RR of anti-HCV positivity (30.3; 95% Cl: 6.1–150.6) were significant for the risk of HCC after adjustment for potentially confounding factors. In contrast, RR of Clonochis sinensis in stool (2.7; 95% Cl: 1.1–6.3) and RR of heavy drinking (4.6; 95% Cl:1.4–15.2) were significant for the risk of CLG. Transfusion history, acupuncture history, and cigarette smoking were not associated with the risk of HCC or CLG.
CONCLUSIONS: Strong evidence indicated that both HBV and HCV infection were independent risk factors for HCC. In contrast, C. sinensis in stools and heavy drinking were associated with the risk of CLG in Korea.
Keywords hepatocellular carcinoma, cholangiocarcinoma, hepatitis B virus, hepatitis C virus, Clonorchis sinensis
Revised 1 February 1996
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