Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by PENTTINEN, J.
Right arrow Articles by VALONEN, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PENTTINEN, J.
Right arrow Articles by VALONEN, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1996 Oxford University Press

research-article

Use of Psychotropic Drugs and Risk of Myocardial Infarction: A Case-Control Study in Finnish Farmers

JYRKI PENTTINEN and PAULIINA VALONEN

Kuopio Regional Institute of Occupational Health PO Box 93, FIN-70701, Kuopio, Finland.

BACKGROUND: In 1992 Thorogood et al. reported an increased risk of myocardial infarction in women using psychotropic drugs. The aim of our study Is to find out whether there Is a link between the use of psychotropic drugs and subsequentmyocardial infarction in males.

METHODS: A cohort of 3172 male farmers was followed from 1 February 1980 to 31 December 1992. Those subjects who had myocardial infarction without any previous symptoms dunng the follow-up were considered as cases. For every case three matched controls were selected. The matched variables were age, smoking habits, social status and county. The final sample includes 83 cases and 249 controls.

RESULTS: Those who had used psychotropic drugs had Increased nsk for myocardial infarction, odds ratio (OR) = 2.5, 95% confidence interval (Cl): 1.2–5 2. Most pronounced risk for myocardial Infarction was found among users of antl-depressants, OR = 5.4 (Cl : 1.8–16.1).

CONCLUSIONS: The use of psychotropic drugs, especially antidepressants, Is associated with increased nsk of myocardial Infarction. Further attempts are needed to determine whether the relationship between use of psychotropic drugs and risk of myocardial infarction is causal or not.

Keywords myocardial infarction, psychotropic drugs, depression, case-control study, farmers

Revised 1 January 1996


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
A. Nicholson, H. Kuper, and H. Hemingway
Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies
Eur. Heart J., December 1, 2006; 27(23): 2763 - 2774.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
J. Hippisley-Cox, M. Pringle, V. Hammersley, N. Crown, A. Wynn, A. Meal, and C. Coupland
Antidepressants as risk factor for ischaemic heart disease: case-control study in primary care
BMJ, September 22, 2001; 323(7314): 666 - 669.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.