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© 1995 Oxford University Press

research-article

Relation of Fibrinogen to Lifestyles and to Cardiovascular Risk Factors in a Working Population

E DE BOEVER*, D DE BACQUER*,, L BRAECKMAN*, G BAELE**, M ROSSENEU{dagger} and G DE BACKER*

* Department of Public Health, University of Gent De Pintelaan 185, B-9000 Gent, Belgium.
** Coagulation Laboratory, University Hospital Gent, Belgium.
{dagger} Department of Clinical Chemistry A Z St Jan, Brugge, Belgium.

Reprint requests to: D De Bacquer.

BACKGROUND: The association between fibrinogen and smoking behaviour, age, body mass index, blood pressure, heart rate and plasma lipid profile, was assessed in a cohort of middle-aged working men.

METHODS: Seven hundred and forty five subjects were examined as part of a health intervention programme at the worksite. Nine subjects were excluded from the study because of prevalent diabetes. Correlates of plasma fibrinogen concentrations were evaluated through univariate and multivariate methods

RESULTS: In multiple regression analysis fibnnogen correlated with age, smoking behaviour, apolipoprotein B (apo B) apolipoprotein A-l (apo A-l) and lipoprotein (a) (Lp(a)) levels, which together explained 11% of the variation in fibrinogen concentration. From this model, fibrinogen concentration was associated with an increase of 13.6 mg/dl for every 10 years' increase in age, 28.2 mg/dl if a person smoked, and 4.6 mg/dl and 3.8 mg/dl with a 20 mg/dl rise in respectively apo B and Lp(a). A 20 mg/dl increase in apo A-l concentrations was estimated to be associated with a 6.0 mg/dl lower fibrinogen level.

CONCLUSIONS: The data indicate that both biochemical and lifestyle factors are related to the plasma fibnnogen concentration; these interactions may explain partly the relationship between fibrinogen and cardiovascular disease.

Keywords fibrinogen, lipoprotein (a), epidemiology, coronary heart disease

Revised 1 April 1995


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