Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by NORRISH, A.
Right arrow Articles by JACKSON, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NORRISH, A.
Right arrow Articles by JACKSON, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 Oxford University Press

research-article

Do Cardiovascular Disease Risk Factors Predict All-Cause Mortality?

ALAN NORRISH, DIANA NORTH, ROY LAY YEE and RODNEY JACKSON

Department of Community Health, School of Medicine, University of Auckland Private Bag 92 019, Auckland, New Zealand.

BACKGROUND: The purpose of this study is to describe associations between a number of standard cardiovascular risk factors and all-cause mortality.

METHODS: Mortality data were collected for a randomly selected cohort of 1029 New Zealand men aged 35–64 years, followed up over a 9-year period. A proportional hazards regression model was used to estimate the relative risks (RR) for all-cause mortality associated with a number of cardiovascular risk factors.

RESULTS: In all, 96 deaths occurred over the 9-year period, of which 50% were due to cardiovascular causes. All-cause mortality was positively associated with cigarette smoking (age-adjusted RR = 2.01, 95% CI : 1.15–3.53, current versus never), systolic blood pressure (age-adjusted RR = 2.18, 95% CI : 1.23–4.44, upper versus lower tertile), and body mass index (age-adjusted RR = 1.59, 95% CI : 0.94–2.66, upper versus lower tertile) and inversely associated with high density lipoprotein (HDL)-cholesterol (age-adjusted RR = 0.45, 95% CI : 0.25–0.80, upper versus lower tertile). All-cause mortality was only weakly associated with serum total cholesterol (age-adjusted RR = 1.19, 95% CI : 0.70–1.99, upper versus lower tertile), and there was no evidence of a U-shaped relationship for this risk factor. There was an inverse association between all-cause mortality and socioeconomic status (age-adjusted RR = 1.70, 95% CI : 1.03–2.80, lower versus upper). Light alcohol consumption was associated with reduced all-cause mortality (age-adjusted RR = 0.63, 95% CI : 0.37–1.05, light versus teetotal), but this benefit did not persist for alcohol consumption above about three standard drinks per day.

CONCLUSIONS: The findings of this study indicate that the standard cardiovascular risk factors are likely to have a beneficial impact on all-cause mortality as well as cardiovascular disease in middle-aged and older men.

Keywords coronary heart disease, risk factors, all-cause mortality, Cox proportional hazards model

Revised 1 April 1995


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch SurgHome page
M. Delgado-Rodriguez, M. Medina-Cuadros, A. Gomez-Ortega, G. Martinez-Gallego, M. Mariscal-Ortiz, M. A. Martinez-Gonzalez, and M. Sillero-Arenas
Cholesterol and Serum Albumin Levels as Predictors of Cross Infection, Death, and Length of Hospital Stay
Arch Surg, July 1, 2002; 137(7): 805 - 812.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.