Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by ASTAGNEAU, P.
Right arrow Articles by DELORON, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ASTAGNEAU, P.
Right arrow Articles by DELORON, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1994 Oxford University Press

other

Antibodies to the 4-mer Repeat of the Ring-Infected Erythrocyte Surface Antigen (Pf155/RESA) Protect against Plasmodium falciparum Malaria

PASCAL ASTAGNEAU*, CLAIRE CHOUGNET*, JEAN PAUL LEPERS{dagger}, MARIE DANIELLE ANDRIAMANGATIANA-RASON{dagger} and PHILIPPE DELORON*

*INSERM Unité 13 and Institut de Médecine et d'Epidémiologie Africaines (IMEA) 190 Boulevard MacDonald, 75019 Paris, France
{dagger}Unité de recherche sur le paludisme, Institut Pasteur de Madagascar BP 1274, Antananarivo, Madagascar

Astagneau P (INSERM Unite 13 and Institut de Medecine et d'Epidemiologie Africaines (IMEA), 190 Boulevard MacDonald, 75019 Paris, France), Chougnet C, Lepers J P, Andriamangatiana-Rason M D and Deloron P. Antibodies to the 4-mer repeat of the ring-infected erythrocyte surface antigen (Pf155/RESA) protect against Plasmodium falciparum malaria. International Journal of Epidemiology 1994; 23: 169–175.

To investigate the protective role of antibodies to the ring-infected erythrocyte surface antigen (Pf155/RESA) epitopes against Plasmodium falciparum clinical malaria, a cohort study was conducted in a Malagasy village over 7 months. In the 304 individuals included, 127 experienced P. falciparum attacks of under 1500 parasites/µl with no clinical symptoms (protected individuals) and 177 experienced at least one clinical or preclinical P. falciparum attack requiring therapy (unprotected individuals). Antibodies to whole Pf155/RESA, to single epitopes of the 3' terminus, (EENV) and EENVEHDA(EENV)2 had higher responses in protected than in unprotected individuals (P=0.006, P=0.005, P=0.05 respectively). Within the whole pattem of antibodies to the Pf155/RESA epitopes. only anti-R4 was related to protection independently of age and anti-wR. The Pf155/RESA 4-mer repeated epitope might be of interest for inclusion in a vaccine against the asexual blood stages of P. falciparum.

Received 1 July 1993


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
C. G. Adda, L. Tilley, R. F. Anders, and M. Foley
Isolation of Peptides That Mimic Epitopes on a Malarial Antigen from Random Peptide Libraries Displayed on Phage
Infect. Immun., September 1, 1999; 67(9): 4679 - 4688.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.