International Journal of Epidemiology, Vol 22, S113-S120, Copyright © 1993 by International Epidemiological Association
D Luce, M Gerin, F Berrino, P Pisani and A Leclerc
Two methods used for retrospective evaluation of occupational exposures, a
case by case assessment by expert and the application of a job exposure
matrix (JEM), are compared using occupational histories collected for a
case-control study on sinonasal cancer. The objective was to identify the
main sources of discrepancies and to contribute to an optimal use of a JEM
for population-based case-control studies. Comparisons were based on job
periods, and were performed separately for two substances: formaldehyde and
wood-dust. Job periods were classified according to the category of
exposure assigned by the matrix, and to the probability and level of
exposure assessed by the study expert. The sources of discrepancies were
examined for job periods probably or definitely exposed according to the
JEM and unexposed for the expert, or unexposed in the JEM and probably or
definitely exposed to medium or high level for the expert. Such
discrepancies were observed for 8% of the job periods for formaldehyde and
3% of the job periods for wood-dust. The agreement between the two
approaches was better for wood-dust than for formaldehyde. The relative
importance of different sources of discrepancies was not the same for
formaldehyde and wood-dust. For formaldehyde a substantial part of the
discrepancies was due to disagreements between the study expert and the
matrix experts, which were mostly differences in threshold limits between
'not exposed' and 'definitely exposed at a low level'. Differences between
experts' opinions did not explain the discordances observed for wood-dust.
The presence of additional information in the questionnaire was an
important source of discrepancy for the two substances.(ABSTRACT TRUNCATED
AT 250 WORDS)
ARTICLES
Sources of discrepancies between a job exposure matrix and a case by case expert assessment for occupational exposure to formaldehyde and wood-dust
INSERM U.88, Paris, France.
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