Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (28)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by MALVY, D. J-M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MALVY, D. J-M
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 Oxford University Press

other

Serum Beta-Carotene and Antioxidant Micronutrients in Children with Cancer

DENIS J-M MALVY*,**,, BERNARD BURTSCHY{dagger}, JOSIANE ARNAUD{ddagger}, DANIELE SOMMELET§, GUY LEVERGER|, LUDMILA DOSTALOVA, JACQUES DRUCKER**, OLIVIER AMEDEE-MANESME* and THE ‘CANCER IN CHILDREN AND ANTIOXIDANT MICRONUTRIENTS’ FRENCH STUDY GROUP#

* Unité de recherches en Hépatologie pédiatrique INSERM UO56 and Department of Pediatrics, Centre Hospitalier de Bicêtre 78 rue du Général Leclerc, F-94275 Bicêtre Cedex, France
** Laboratory of Public Health, University of Medicine 2 bis Boulevard Tonnellé. F-37044 Tours Cedex, France
{dagger} Statistical Unit, Télécom Paris 46 rue Barrault, F-75634 Paris Cedex 13, France
{ddagger} Laboratory of Biochemistry C, Centre Hospitalier Universitaire F-38043 Grenoble Cedex, France
§ Department of Pediatrics ‘II’. Hôpital d'enfants, Centre Hospitalier de Nancy rue du Morvan F-54511 Vandoeuvre Cedex, France
| Department of Pediatric Hematology, Hôpital St Louis 1 rue Cl. Vellefaux, F-75010 Paris, France
Department of Clinical Nutrition F Hoffman - La Roche CH-4002 Basel, Switzerland

Reprint requests to: Dr. D Malvy

Serum antioxidant vitamins A (retinol) and E ({alpha}-tocopherol), ß-carotene, zinc and selenium for 418 children with newly diagnosed malignancy were compared with those of 632 cancer-free controls. Incident cancer cases and controls were 1–16 years old and recruited in 1986–1989. Age- and sex-adjusted serum concentrations of retinol, ß-carotene and {alpha}-tocopherol were significantly inversely associated with cancer. In similar models, the odds ratio (OR) comparing the highest with the lowest quintile was 2.06 (95% confidence interval [CI] 1.40–3.02) for retinol, 3.87 (95% CI:2.54–5.90) for ß-carotene, 2.15 (95% CI:1.48–3.10) for {alpha}-tocopherol, 1.29 (95% CI:0.75–2.23) for selenium, and 1.94 (95% CI:1.17–2.23) for zinc. The cancer sites that were associated with serum ß-carotene were, in general, leukaemia, lymphoma, central nervous system, bone and renal tumours. Moreover, leukaemia was associated with low mean serum levels of retinol, selenium and zinc. Subjects with lymphoma, bone and renal tumours also had lower mean retinol and {alpha}-tocopherol levels than controls. Brain tumour patients had low vitamin E levels. Low serum values of antioxidant vitamins were associated with childhood neoplasm occurrence. Some site-specific effect was reported. Low peripheral nutrient levels are not considered as cancer promoters but rather as an impairment of the body's defence mechanism occurring during the cancer-related metabolic and nutritional disturbances and inflammation processes.

Received 1 March 1993


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Am. Coll. Nutr.Home page
C. D. Gokhale, S. A. Udipi, R. Y. Ambaye, S. K. Pai, and S. H. Advani
Post-Therapy Profile of Serum Total Cholesterol, Retinol and Zinc in Pediatric Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma
J. Am. Coll. Nutr., February 1, 2007; 26(1): 49 - 56.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.