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© 1992 Oxford University Press

other

The Measurement and Interpretation of Age-Specific Vaccine Efficacy

C P FARRINGTON

Communicable Disease Surveillance Centre 61 Colindale Avenue, London NW9 5EQ. UK

Farrrington C P (Communicable Disease Surveillance Centre, 61 Colindale Avenue, London NW9 5EQ, UK). The measurement and interpretation of age-specific vaccine efficacy. International Journal of Epidemiology 1992; 21: 1014–1020.

The age-specific efficacy of a vaccine depends upon the mechanism of vaccine action and the force of infection in the unvaccinated subpopulation. Consequently, inferences concerning the persistence of vaccine-induced immunity cannot in general be made directly from age-specific vaccine efficacy estimates. The definition, estimation and interpretation of age-specific vaccine efficacy measures are discussed using simple models of vaccine action. The methods are applied to data on measles and pertussis vaccines.

Received 1 March 1992


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