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© 1992 Oxford University Press

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Ancestral Origin of Insulin-Dependent Diabetes in Mexican-Americans

SYLVIA J SHAW*, CONSTANCE M VADHEIM{dagger}, JEROME I ROTTER{dagger}, GERTRUDE COSTIN*;, YORDANKA BESHKOV* and ADlNA ZEIDLER*

*Los Angeles County-University of Southem California Medical Center and Childreus Hospital of Los Angela 1200 North State Street, Room 8250. Los Angeles, CA 90033. USA
{dagger}Medical Genetics Birth Defects Center, Departments of Medicine and Pediaries, Cedars-Sinai Medical Center and UCLA School of Medicine USA

Shaw S J (University of Southem California Medical Center, 1200 North State Street, Los Angeles, CA 90033, USA), Vadheim C M, Rotter J I, Costin G, Beshkov Y and Zeidler A. Ancestral origin of insulin-dependent diabetes in Mexican-Americans. International Journal of Epidemiology 1992; 21: 725–729.

To test the hypothesis that insulin-dependent diabetes mellitus in the Mexican-American population is due to Spanish genetic admixture, we obtained ancestral information on 106 Mexican-American familias with an insulin-dependent diabetic index case and 80 Mexican-American control families from 1987 to 1991. The Mexican states of origin were available on 395 grandparents of the insulin-dependent diabetic index cases and 291 grandparents of the controls. Analysis of the individual states of origin revealed that there were significantly more Mexican-American grandparents of diabetic index cases from the states of Jalisco and Michoacan when compared to the control families (31% and 16% diabetic versus 22% and 11% controls respectively, P < 0.01 ). The states of Zacatecas and Durango had a lower f requency of diabetic grandparents as compared to controls (6% diabetic versus 12% controls, P < 0.001). Analysis of the origin by Northem and Southern states of Mexico revealed a significant decrease in the number of grandparents of the insulin-dependent diabetic cases from the Northern regions of Mexico, 19.5%, versus 32% in controls, (P < 0.001). These data indicate that the grandparents of the insulin-dependent diabetic index cases originate from states and regions of Mexico which were those of the early entry of the Europeans. These data thus support the hypothesis that insulin-dependent diabetes mellitus in the Mexican-American population may be due in significant part to an original genetic contribution from the Spanish-European population.

Received 1 February 1992


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