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© 1992 Oxford University Press

other

Assessment of the Spatial Occurrence of Childhood Leukaemia Mortality Using Standardized Rate Ratios with a Simple Linear Poisson Model

MIKEL AICKIN*,{dagger}, CHARLES A CHAPIN{dagger}, TIMOTHY J FLOOD{dagger}, STEVEN J ENGLENDER{dagger} and GLYN G CALDWELL{dagger}

*Department of Family and Community Medicine, University of Arizona Tucson, USA
{dagger}Division of Disease Prevention Services, Arizona Department of Health Services Phoenix. Arizona. USA

Reprint requests to: M. Aickin. Department of Family and Community Medicine, Arizona Health Sciences Center, 1501 N Campbell, Tucson. AZ 85724. USA

Aickin M (Department of Family and Community Medicine, University of Arizona, Tucson, Arizona, USA), Chapin C A, Flood T J, Englender S J and Caldwell G G. Assassment of the spatial occurrence of childhood leukaemia mortality using standardized rate ratios with a simple linear Poisson model. International Journal of Epidemiology 1992; 21: 649–655.

Reports of a suspected cluster of childhood leukaemia cases in West Central Phoenix have led to a number of epidemiological studies in the geographical area. We report here on a death certificate-based mortality study, which indicated an elevated rate ratio of 1.95 during 1966–1988, using the remainder of the Phoenix standard metropolitan statistical area (SMSA) as a comparison region. In the process of analysing the data from this study, a methodology for dealing with denominator variability in a standardized mortality ratio was developed using a simple linear Poisson model. This new approach is seen as being of general use in the analysis of standardized rate ratios (SRR), as well as being particularly appropriate for cluster investigations.

Received 1 November 1991


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