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© 1992 Oxford University Press

research-article

Relationship between the Degree of Individual Space-Time Clustering and Age at Onset of Disease among Multiple Sclerosis Patients

TROND RIISE* and MELVILLE R KLAUBER{dagger}

* Section for Medical Informatics and Statistics, University of Bergen Armauer Hansens Building. N-5021 Bergen, Norway
{dagger} Department of Community and I amily Medicine. University of California at San Diego USA

A previous study of 381 multiple sclerosis (MS) patients from Norway has shown significant clustering of residence in adolescence among contemporaneous patients. Using a regression model with individual degree of clustering determined by Monte Carlo methods, this study utilizes the same data and shows a significant correlation (P = 0.002) between the degree of clustering and age at clinical onset of disease. A high degree of clustering in adolescence indicated a low age at clinical onset. This association was also verified independently of the regression model. The finding supports the theory of a common viral agent acting epidemically among nonpre-exposed individuals during adolescence, with MS developing in individuals with other necessary factors, such as a genetic predisposition.

Received 1 December 1991


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