Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by PEKKANEN, J.
Right arrow Articles by KARVONEN, M. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PEKKANEN, J.
Right arrow Articles by KARVONEN, M. J
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 Oxford University Press

research-article

Risk Factor Dynamics, Mortality and Life Expectancy Differences between Eastern and Western Finland: The Finnish Cohorts of the Seven Countries Study

JUHA PEKKANEN*, KENNETH G MANTON**,, ERIC STALLARD**, AULIKKI NISSINEN{dagger} and MARTTI J KARVONEN{dagger}

* Department of Epidemiology, National Public Health Institute Helsinki, Finland
** Center for Demographic Studies, Duke University 2117 Campus Drive, Durhan, NC 27706, USA
{dagger}Department of Public Health, University of Kuopio Kuoplo, Finland
{ddagger} Pioppi, Italy

Reprint requests to: Kenneth G Manton

Prior studies have not accounted for male mortality being higher in east than west Finland. Efforts to identify the mechanisms producing higher mortality in the east, due primarily to cardiovascular diseases (CVD), initially focused on a search for new risk factors. An alternate approach is to examine the assumptions of the analysis. This was investigated using a model which described (a) changes in risk factors over time, (b) dependency of risk factor effects on age, and (c) interactions and nonlinear effects of risk factors on mortality. 1The model was applied to 25-year follow-up data from cohorts of eastern (N = 823) and western (N = 888) Finnish men using pulse pressure, diastolic blood pressure, body mass index, total cholesterol, vital capacity index, cigarette smoking, and heart rate as risk factors. At age 40, men in the west had a life expectancy 2.4 years higher. Of the difference 29% (0.7 years) was associated with area differences in risk factor means, variances, and their change with age. The remainder, 1.7 years, was associated with age differences in the relation of risk factor interactions to CVD mortality. Possible reasons for these differences, such as joint elevation of several risk factors inducing rapid progression of atherogenesis, are discussed. No significant area differences were observed for mortality from either cancer or other causes.

Received 1 October 1991


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Sci Aging Knowl EnvironHome page
J. Kravchenko, P. J. Goldschmidt-Clermont, T. Powell, E. Stallard, I. Akushevich, M. S. Cuffe, and K. G. Manton
Endothelial Progenitor Cell Therapy for Atherosclerosis: The Philosopher's Stone for an Aging Population?
Sci. Aging Knowl. Environ., June 22, 2005; 2005(25): pe18 - pe18.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.