© 1992 Oxford University Press
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Risk Factors for Epithelial Ovarian Cancer in Beijing, China
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*Department of Obstetrics and Gynaecology Peking Union Medical College, Beijing China
**Department of Biostatistics Peking Union Medical College Beijing China
Environmental Epidemiology Branch, National Cancer Institute Bethesda, MD 20592, USA
Reprint requests to: Louise A. Brinton, Executive Plaza North, Rm. 443, at the above address
Chen Y (Department of Obstetrics and Gynaecology, Peking Union Medical College, Beijing, China). Wu P-C, Lang J-H, Ge W-J, Hartge P and Bnnton LA. Risk factors for epithelial ovarian cancer in Beijing, China. International Journal of Epidemiology 1992; 21: 23–29.
A study in Beijing, China of 112 pathologically confirmed epithelial ovarian cancer cases and 224 age-matched community controls enabled evaluation of risk in relation to reproductive, medical, familial, and selected lifestyle factors. An inverse relationship was observed between the number of full-term pregnancies and ovarian cancer risk. Compared to nulliparous women, subjects with one, two, or three full-term pregnancies were at 50%, 70%, or 90% reduced risks, respectively (P for trend <0.01). A positive correlation was found between the number of ovulatory years and risk, with a 2.6-fold increased risk for women with 30 or more compared to less than 10 ovulatory years (P for trend <0.01). Infertility, as estimated in various ways, was also found to be an important risk factor. When parity was taken into account, age at first pregnancy was not related to ovarian cancer risk. No protective effect was associated with mumps virus in fection. In contrast, risk increased significantly as serum mumps virus antibody titres increased (Pfor trend <0.01). An elevated risk was found in women with a history of long-term (>3 months( application of talc-containing dusting powder to the lower abdomen and perineum (Relative risk 3.9, 95% confidence interval: 0.9–10.63). These findings suggest that Chinese women have risk factors similar to those of occidental women.
Received 1 June 1991
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