© 1992 Oxford University Press
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Maternal Smoking in Pregnancy: Does it Increase the Risk of Childhood Cancer?
*Department of Epidemiology, Institute of Environmental Medicine, Karolinska Insitutet Box 60208, S-104 01 and Department of Environmental Health, Karolinaka Hospital Stockholm, Sweden
Department of Public Health and Epidemiology, National Board of Health and Welfare Stockholm, Sweden
Pershagen G (Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 60208, S-104 01 Stockholm, Sweden), Ericson A and Otterblad-Olausson P. Maternal smoking in pregnancy: does it increase the risk of childhood cancer? International Journal of Epidemiology 1992; 21: 1–5.
Experimental studies show that some compounds in tobacco smoke are transpiacental carcinogens, but epidemio logical data on maternal smoking and childhood cancer are inconclusive. Using the national Swedish Medical Birth and Cancer Registries, the incidence of cancer was followed through 1987 in a cohort of 497051 children bom 1982–1987 for whom information was available on maternal smoking at 2–3 months of pregnancy. A total of 327 cancers appeared including 198 solid tumours and 129 cancers of the lymphatic and haematopoletic system. The overall relative risk for cancer in children with mothers reporting smoking during pregnancy was 0.99 (95% confidence interval (CI):0.78–1.27). Corresponding risks for solid tumours and cancers of the lymphatic/haematopoietic system were 0.96 (0.70–1.32) and 1.04(0.71–1.52), respectively. There was no consistent increase in risk for cancer of different sites or in relation to number of cigarettes smoked per day.
Received 1 August 1991
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