International Journal of Epidemiology, Vol 20, S58-S61, Copyright © 1991 by International Epidemiological Association
AB Graves, CM van Duijn, V Chandra, L Fratiglioni, A Heyman, AF Jorm, E Kokmen, K Kondo, JA Mortimer and WA Rocca
A meta-analysis, involving the secondary analysis of original data from 11
case-control studies of Alzheimer's disease, is presented for occupational
exposures to solvents and lead. Three studies had data on occupational
exposure to solvents. Among cases, 21.3% were reported to have been
exposed; among controls, this figure was comparable (20.9%). This yielded a
pooled matched relative risk of 0.76 (95% CI: 0.47- 1.23). Four studies had
data on exposure to lead. Exposure frequencies were 6.1% in cases and 8.3%
in controls. This resulted in a pooled matched relative risk of 0.71 (95%
CI: 0.36-1.41). The meta-analysis was particularly useful in validating
negative results from individual studies and in increasing the statistical
power for the analysis of lead exposure, where stratum-specific cell sizes
were frequently smaller than five in individual studies. However, since
exposure in the various studies was ascertained in a rather broad manner,
prospective studies are recommended which focus on high-risk occupational
populations and which determine the incidence of Alzheimer's disease in
these and comparable unexposed populations.
ARTICLES
Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group
Health and Population Research Center, Battelle Seattle Research Center, Seattle, WA 98105.
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