International Journal of Epidemiology, Vol 20, S43-S47, Copyright © 1991 by International Epidemiological Association
AF Jorm, CM van Duijn, V Chandra, L Fratiglioni, AB Graves, A Heyman, E Kokmen, K Kondo, JA Mortimer and WA Rocca
Data from case-control studies of Alzheimer's disease (AD) were pooled to
examine the possible roles of history of depression, anti-depressant
treatment and adverse life events as risk factors. History of depression
was found to be associated with AD, although the effect was confined to
late onset cases. The association held for episodes of depression more than
10 years before AD onset, as well as for episodes occurring within a decade
of onset. No association was found with anti- depressant treatment.
However, data were only available from two studies, limiting the power of
the analysis. Also, no association was found with the three major life
events considered in the pooled analysis: death of spouse, death of a child
and divorce.
ARTICLES
Psychiatric history and related exposures as risk factors for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group
NH and MRC Social Psychiatry Research Unit, Australian National University, Canberra.
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