International Journal of Epidemiology, Vol 20, S36-S42, Copyright © 1991 by International Epidemiological Association
MM Breteler, CM van Duijn, V Chandra, L Fratiglioni, AB Graves, A Heyman, AF Jorm, E Kokmen, K Kondo and JA Mortimer
In a re-analysis of eight case-control studies on Alzheimer's disease we
explored several medical conditions that had previously been suggested as
possible risk factors for Alzheimer's disease. History of hypothyroidism
was increased in cases as compared to controls (relative risk 2.3; 95%
confidence interval 1.0-5.4). Severe headaches and migraine were inversely
related to Alzheimer's disease (relative risk 0.7; 95% confidence interval
0.5-1.0). More cases than controls reported epilepsy before onset of
Alzheimer's disease (relative risk 1.6; 95% confidence interval 0.7-3.5),
especially for epilepsy with an onset within 10 years of onset of dementia.
Neurotropic viruses, allergic conditions, general anaesthesia and blood
transfusions were not associated with Alzheimer's disease.
ARTICLES
Medical history and the risk of Alzheimer's disease: a collaborative re- analysis of case-control studies. EURODEM Risk Factors Research Group
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
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