International Journal of Epidemiology, Vol 20, S28-S35, Copyright © 1991 by International Epidemiological Association
JA Mortimer, CM van Duijn, V Chandra, L Fratiglioni, AB Graves, A Heyman, AF Jorm, E Kokmen, K Kondo and WA Rocca
A re-analysis of the data from 11 case-control studies was performed to
investigate the association between head trauma and Alzheimer's disease
(AD). To increase comparability of studies, exposures were limited to head
trauma with loss of consciousness (hereafter referred to as 'head trauma')
and comparisons were restricted to community (versus hospital) controls.
Test for heterogeneity across studies was negative; consequently, data were
pooled in subsequent analyses. The pooled relative risk for head trauma was
1.82 (95% confidence interval: 1.26- 2.67). Stratified analyses showed
stronger associations in cases without a positive family history of
dementia and in males (versus females). Adjustment of the pooled relative
risk for family history of dementia, education and alcohol consumption did
not alter significantly the association between head trauma and AD. There
was no interaction effect between head trauma and family history of
dementia, suggesting that these risk factors operate independently. Mean
age of onset was not significantly different in cases with a history of
head trauma compared to cases without such a history. The findings of the
pooled analysis support an association between reported head trauma and AD.
ARTICLES
Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group
Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Minneapolis, Minnesota.
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