International Journal of Epidemiology, Vol 20, S13-S20, Copyright © 1991 by International Epidemiological Association
CM van Duijn, D Clayton, V Chandra, L Fratiglioni, AB Graves, A Heyman, AF Jorm, E Kokmen, K Kondo and JA Mortimer
Case-control studies of Alzheimer's disease were re-analysed to examine the
association of Alzheimer's disease with family history in first degree
relatives of dementia, Down's syndrome and Parkinson's disease. Overall,
the relative risk of Alzheimer's disease for those with at least one first
degree relative with dementia was 3.5 (95% confidence interval 2.6-4.6).
Stratification according to age of onset of Alzheimer's disease showed that
the relative risk decreased with increasing onset age. However, among
patients with an onset of disease after 80 years, there were still
significantly more subjects with one or more first degree relatives with
dementia as compared to controls (relative risk 2.6; 95% confidence
interval 1.3-5.2). The relative risk of Alzheimer's disease was
significantly lower in patients who had one first degree relative with
dementia (relative risk 2.6; 95% confidence interval 2.0-3.5) as compared
to those who had two or more affected relatives (relative risk 7.5; 95%
confidence interval 3.3-16.7). Furthermore, the re-analysis showed a
significant association between Alzheimer's disease and family history of
Down's syndrome (relative risk 2.7; 95% confidence interval 1.2-5.7), which
was strongest in those patients who had a positive family history of
dementia. The relative risk of Alzheimer's disease for those with a
positive family history of Parkinson's disease was 2.4 (95% confidence
interval 1.0- 5.8).
ARTICLES
Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. S. Bassett, D. M. Yousem, C. Cristinzio, I. Kusevic, M. A. Yassa, B. S. Caffo, and S. L. Zeger Familial risk for Alzheimer's disease alters fMRI activation patterns Brain, May 1, 2006; 129(5): 1229 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sleegers, G. Roks, J. Theuns, Y. S. Aulchenko, R. Rademakers, M. Cruts, W. A. van Gool, C. Van Broeckhoven, P. Heutink, B. A. Oostra, et al. Familial clustering and genetic risk for dementia in a genetically isolated Dutch population Brain, July 1, 2004; 127(7): 1641 - 1649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Elbaz and A. Alperovitch Bias in Association Studies Resulting from Gene-Environment Interactions and Competing Risks Am. J. Epidemiol., February 1, 2002; 155(3): 265 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L Tyas, J. Manfreda, L. A Strain, and P. R Montgomery Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada Int. J. Epidemiol., June 1, 2001; 30(3): 590 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Smith, A. H. Andersen, R. J. Kryscio, F. A. Schmitt, M. S. Kindy, L. X. Blonder, and M. J. Avison Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease Neurology, October 22, 1999; 53(7): 1391 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Elbaz, F. Grigoletto, M. Baldereschi, M. M. Breteler, J. M. Manubens-Bertran, S. Lopez-Pousa, J. F. Dartigues, A. Alperovitch, C. Tzourio, and W. A. Rocca Familial aggregation of Parkinson's disease: A population-based case-control study in Europe Neurology, June 1, 1999; 52(9): 1876 - 1876. [Abstract] [Full Text]
|
|
|
|
|
|
K. Marder, M.-X. Tang, B. Alfaro, H. Mejia, L. Cote, E. Louis, Y. Stern, and R. Mayeux Risk of Alzheimer's disease in relatives of Parkinson's disease patients with and without dementia Neurology, March 1, 1999; 52(4): 719 - 719. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Schellenberg, T. Bird, E. Wijsman, H. Orr, L Anderson, E Nemens, J. White, L Bonnycastle, J. Weber, M. Alonso, et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14 Science, October 23, 1992; 258(5082): 668 - 671. [Abstract] [PDF]
|
|