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© 1991 Oxford University Press

research-article

Response to Hepatitis B Vaccine in Relation to the Hepatitis B Status of Family Members

H M INSKIP*, A J HALL*, I K TEMPLE{dagger}, F LOIK*, E HERBAGE{dagger}, J CHOTARD* and H WHITTLE{dagger}

*International Agency for Research on Cancer, c/o MRC Laboratories PO Box 237, Fajara, Banjul, The Gambia, West Africa.
{dagger}MRC Laboratories Fajara, Nr Banjul, The Gambia.

The influence of the hepatitis B status of family members on the response to hepatitis B vaccine of an infant has been examined in 395 families. The presence of one or more HBsAg-positive family members did not appear to have any effect on the vaccine response. This is an encouraging finding as children born into carrier familes are at anincreased risk of becoming carriers themselves. That the vaccine response of such children is as good as for those bourn into non-carrier familes means that they are likely to be protected against the carrier state by the vaccine.

Revised 1 March 1991


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