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© 1991 Oxford University Press

research-article

Hepatitis B Vaccine in the Gambian Expanded Programme on Immunization: Factors Influencing Antibody Response

H M INSKIP*, A J HALL*, J CHOTARD*, F LOIK* and H WHITTLE{dagger}

*International Agency for Research on Cancer c/o MRC Laboratories Fajaria, PO Box 273, Banjul, The Gambia, West Africa.
{dagger}MRC Laboratories Fajara, Nr Banjul, The Gambia.

Data on over a thousand Gambian children have been analysed to examine factors influencing their antibody levels following immunization with hepatitis B vanccine administered during the first year of life. The dominant effect was the time between the last dose of vaccine and taking the blood sample. There was considerable variation in vaccine response by area of residernce which could not be explained by any other factor. The hepatitis B surface antigen (HBsAg) status of the mother and the age at vaccination did not appear to have an effect, but there was some Indication that a delay in receiving the second does of vaccine led to a marginally lower response.

Revised 1 February 1991


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