Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by NAROD, S. A
Right arrow Articles by LENOIR, G. M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NAROD, S. A
Right arrow Articles by LENOIR, G. M
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1991 Oxford University Press

research-article

Are Bilateral Tumours Hereditary?

STEVEN A NAROD* and GILBERT M LENOIR**

*Programme on Viral and Hereditary Factors, Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer 150 Cours Albert Thomas, Lyon 69372, France
**Present address: McGill University, The Montreal General Hospital, Research Institute 21650 Cedar Avenue, Room Livingston 10803, Montreal PQ H3G 1A4, Canada.

Early observations regarding the age of onset, the family history and the clinical pattern of presentation of Wilms' tumour patients have been used to support the two-hit model of carcinogenesis, and to infer the hereditary nature of the bilateral form of the disease. Recent observations drawn from follow-up studies of offspring of unilaterally affected patients cast serious doubts upon the claim that a bilateral tumour implies the presence of an inherited predisposing mutation.

Revised 1 August 1990


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.