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International Journal of Epidemiology, Vol 19, S8-10, Copyright © 1990 by International Epidemiological Association

ARTICLES

Histopathology of lung cancer

DT Carr
Department of Internal Medicine, MD Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Houston.

Lung cancer is a complex problem because there are a number of different histological cell types. Those commonly grouped as bronchogenic carcinoma (epidermoid carcinoma, adenocarcinoma, large cell undifferentiated carcinoma, small cell carcinoma, and adenosquamous carcinoma) account for more than 90% of the new cases and the deaths each year. The natural history of bronchogenic carcinoma suggests that many years pass while the cancer evolves from a pre- cancerous change in the bronchial mucosa, to undetectable microscopic cancer, to preclinical asymptomatic cancer and finally into a full symptomatic cancer, the phase of most lung malignancies in the tissue at diagnosis. Therefore, students of the aetiology of this disease must consider what has happened to patients 5-20 years before lung cancer is diagnosed.
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