Skip Navigation

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Brittebo, E. B.
Right arrow Articles by Brandt, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brittebo, E. B.
Right arrow Articles by Brandt, I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

International Journal of Epidemiology, Vol 19, S24-S31, Copyright © 1990 by International Epidemiological Association

ARTICLES

Interactions of xenobiotics in the respiratory tract following non- inhalation routes of exposure

EB Brittebo and I Brandt
Department of Pharmacology and Toxicology, Uppsala Biomedical Centre, Sweden.

Compounds of highly variable structure may induce toxic effects and tumours in the respiratory tract following peroral or parenteral administration in experimental animals. Such compounds are used in industrial processes or may be present in the food as contaminants or pesticide residues. This review gives examples of selective metabolism and toxicity of chemicals in different segments of the respiratory tract. Many of these compounds require metabolic activation to exert toxicity. Accordingly, the susceptibility of the respiratory tract to the effects of such agents may be influenced by other compounds modulating the activity of activating xenobiotic metabolizing enzymes. Dietary factors may alter the susceptibility to experimental lung carcinogenesis also via other mechanisms. As concluded from experimental data, the human lung may be exposed to a wide array of potentially toxic compounds present in the diet or the environment. Such exposures may constitute confounding factors in low-risk lung cancer epidemiology.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.