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© 1990 Oxford University Press

research-article

A Seral Epidemiological Study of HIV Transmitted through Human Seral {Gamma}Globulin Preparations

LI JIN*, JIANG DEHUA*, WANG LIANFU*, ZENG YI**, LI DI{dagger}, LI GUOXUN*, LIU YUYING{ddagger}, SHAO YIMING**, ZHU ZIZHONG§, KONG JING§, FENG XIANXUN*, JING SHINING, WANG JIANboxV and LIU JINXIANG{dagger}{dagger}

* Jining Hygiene and Antiepidemic Station 27 Gong Qingtuan Road, Jinig City, Shandong 272145 People's Republic of China
** Chinese Academy of Preventive Medicine Beijing, China
{dagger}The TV University of Shengli Oil Field China
{ddagger}Jining No. 1 Hospital, Shandong China
§Jining Medical College China
The Road Transportation Company. Hospital of Jining City China
boxVJining Hygien Bureau Shandong, China
{dagger}{dagger}Yanzhou County Hospital Shandong, China

In order to study the potential risk of transferring HIV through human seral {Gamma}-globulin preparations (immunoglobulin), indirect immunofluorescent antibody test (IFA) and Western Blot (WB) assay were applied to 343 random samples (sera) with previous injection of imported human seral {Gamma}-globulins (Ig) positive for Human Immunodeficiency Virus (HIV) antibodies between 1981–1987 for the detection of HIV antibodies. All results were negative and tests on all 23 controls who had previously received Ig made in China also gave negative results. However all 12 batches of imported Ig collected from the above-mentioned users, were positive for HIV antibodies when tested by WB and IFA. This study shows that under normal conditions, human seral {Gamma}-globulin does not transmit HIV.

Received 1 March 1990


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