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© 1990 Oxford University Press

research-article

Lathyrism in Rural Northwestern Ethiopia: A Highly Prevalent Neurotoxic Disorder

REDDA TEKLE HAIMANOT*, YEMANE KIDANE**, ELIZABETH WUHIB**, ANGELINA KALISSA**, TADESSE ALEMU*, ZEIN AHMED ZEIN{dagger} and PETER S SPENCER{ddagger}

*Faculty of Medicine PO Box 4147, Addis Ababa University, Addis Ababa, Ethiopia
**Ethiopian Nutrition Institute Addis Ababa, Ethiopia
{dagger}Gondar College of Medical Sciences, Addis Ababa University Gondar, Ethiopia
{ddagger}Center for Research on Occupational and Environmental Toxicology, Oregon Health Sciences University Portland, Oregon 97201, USA

Haimanot R T (Faculty of Medicine, PO Box 4147, Addis Ababa University, Addis Ababa, Ethiopia), Kidane Y, Wuhib E, Kalissa A, Alemu T, Zein Z A and Spencer P S. Lathyrism in rural northwestern Ethiopia: A highly prevalent neurotoxic disorder. International Journal of Epidemiology 1990, 19: 664–672.

Lathyrism is a disorder of the central motor system, induced by heavy consumption of the grass-pea, Lathyrus sativus an environmentally tolerant legume containing the neurotoxic excitatory amino acid beta-N-oxalylamino-L-alanine (BOAA). A complete door-to-door resurvey of the Dembia and Fogera regions of northwestern Ethiopia, areas endemic for lathyrism, revealed an estimated mean disease prevalence of 0.6%-2.9%. Most patients developed the disease in the epidemic of 1976/77, although new cases appear to have occurred with an estimated mean annual incidence of 1.7: 10 000. Production and consumption of grass-pea is increasing in Ethiopia, making attempts to develop low-BOAA strains to prevent lathyrism increasingly important.


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