© 1990 Oxford University Press
research-article |
Myocardial Infarction is Inversely Associated with Plasma 25-Hydroxyvitamin D3 Levels: A Community-Based Study
*Department of Community Health, University of Auckland , Private Bag, Auckland, New Zealand.
Department of Endocrinology, Auckland Hospital Auckland, New Zealand.
Scragg R (Department of Community Health, University of Auckland, Private Bag, Auckland, New Zealand), Jackson R, Holdaway I M, Lim T and Beaglehole R. Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: A community-based study. International Journal of Epidemiology 1990; 19: 559–563.
The relation between the plasma level of 25-hydroxyvitamin D3, the main metabolite of sun-induced vitamin D, and myocardial infarction (MI) was investigated in a community-based case-control study. Some 179 MI patients presenting to hospital within 12 hours of the onset of symptoms were individually matched with controls by age, sex and date of blood collection. MI patients had significantly lower mean 25-hydroxyvitamin D3 levels than controls (32.0 versus 35.5 nmol/L; p = 0.017), with the case-control differences being greatest in winter and spring. The relative risk of MI for subjects with 25-hydroxyvitomin D3 levels equal to or above the median was 0.43 (95% confidence limits = 0.27, 0.69) compared to subjects below the median. The decrease in MI risk associated with raised vitamin D3 levels was observed in all seasons. These results provide support for the hypothesis that increased exposure to sunlight is protective against coronary heart disease.
Revised 1 December 1989
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. S. K. Wong, R. Delansorne, R. Y. K. Man, and P. M. Vanhoutte Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H289 - H296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Scragg and C. A. Camargo Jr Frequency of Leisure-Time Physical Activity and Serum 25-Hydroxyvitamin D Levels in the US Population: Results from the Third National Health and Nutrition Examination Survey Am. J. Epidemiol., June 25, 2008; (2008) kwn163v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Giovannucci, Y. Liu, B. W. Hollis, and E. B. Rimm 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study Arch Intern Med, June 9, 2008; 168(11): 1174 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Melamed, P. Muntner, E. D. Michos, J. Uribarri, C. Weber, J. Sharma, and P. Raggi Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001 to 2004 Arterioscler. Thromb. Vasc. Biol., June 1, 2008; 28(6): 1179 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Wang, M. J. Pencina, S. L. Booth, P. F. Jacques, E. Ingelsson, K. Lanier, E. J. Benjamin, R. B. D'Agostino, M. Wolf, and R. S. Vasan Vitamin D Deficiency and Risk of Cardiovascular Disease Circulation, January 29, 2008; 117(4): 503 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Michos and R. S. Blumenthal Vitamin D Supplementation and Cardiovascular Disease Risk Circulation, February 20, 2007; 115(7): 827 - 828. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Visser, D. J. Deeg, M. T. Puts, J. C Seidell, and P. Lips Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission. Am. J. Clinical Nutrition, September 1, 2006; 84(3): 616 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Harris Vitamin D and African Americans J. Nutr., April 1, 2006; 136(4): 1126 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Garland, F. C. Garland, E. D. Gorham, M. Lipkin, H. Newmark, S. B. Mohr, and M. F. Holick The Role of Vitamin D in Cancer Prevention Am J Public Health, February 1, 2006; 96(2): 252 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. N. Black and R. Scragg Relationship Between Serum 25-Hydroxyvitamin D and Pulmonary Function in the Third National Health and Nutrition Examination Survey Chest, December 1, 2005; 128(6): 3792 - 3798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tonelli, F. Sacks, M. Pfeffer, Z. Gao, G. Curhan, and for the Cholesterol And Recurrent Events (CARE) Tr Relation Between Serum Phosphate Level and Cardiovascular Event Rate in People With Coronary Disease Circulation, October 25, 2005; 112(17): 2627 - 2633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W G. John, K. Noonan, N. Mannan, and B. J Boucher Hypovitaminosis D is associated with reductions in serum apolipoprotein A-I but not with fasting lipids in British Bangladeshis Am. J. Clinical Nutrition, September 1, 2005; 82(3): 517 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Vieth, R. Scragg, P.E. Norman, and J.T. Powell Vitamin D Nutrition Does Not Cause Peripheral Artery Disease Arterioscler. Thromb. Vasc. Biol., May 1, 2005; 25(5): e41 - e42. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Teng, M. Wolf, M. N. Ofsthun, J. M. Lazarus, M. A. Hernan, C. A. Camargo Jr, and R. Thadhani Activated Injectable Vitamin D and Hemodialysis Survival: A Historical Cohort Study J. Am. Soc. Nephrol., April 1, 2005; 16(4): 1115 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.E. Norman and J.T. Powell Vitamin D, Shedding Light on the Development of Disease in Peripheral Arteries Arterioscler. Thromb. Vasc. Biol., January 1, 2005; 25(1): 39 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J Boucher, W G. John, and K. Noonan Hypovitaminosis D is associated with insulin resistance and {beta} cell dysfunction Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1666 - 1666. [Full Text] [PDF]
|
|
|
|
 |
|
 D. P Trivedi, R. Doll, and K. T. Khaw Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial BMJ, March 1, 2003; 326(7387): 469 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pfeifer, B. Begerow, H. W. Minne, D. Nachtigall, and C. Hansen Effects of a Short-Term Vitamin D3 and Calcium Supplementation on Blood Pressure and Parathyroid Hormone Levels in Elderly Women J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1633 - 1637. [Abstract] [Full Text]
|
|
|
|
|
|
A. R Ness, S. J Frankel, D. J Gunnell, and G. D. Smith Are we really dying for a tan? BMJ, July 10, 1999; 319(7202): 114 - 116. [Full Text]
|
|
|
|
 |
|
 F. J. Van schooten, A. Hirvonen, L. M. Maas, B. A. De mol, J. C. S. kleinjans, D. A. Bell, and J. D. Durrer Putative susceptibility markers of coronary artery disease: association between VDR genotype, smoking, and aromatic DNA adduct levels in human right atrial tissue FASEB J, October 1, 1998; 12(13): 1409 - 1417. [Abstract] [Full Text]
|
|
|
|
|
|
B. R. Walker, R. Best, J. P. Noon, G. C. M. Watt, and D. J. Webb Seasonal Variation in Glucocorticoid Activity in Healthy Men J. Clin. Endocrinol. Metab., December 1, 1997; 82(12): 4015 - 4019. [Abstract] [Full Text] [PDF]
|
|