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© 1990 Oxford University Press

research-article

Familial Clustering of Neural Tube Defects and Gastric Cancer

DWIGHT T JANERICH*, SUSAN TAYLOR MAYNE*, W DOUGLAS THOMPSON**, ALICE D STARK{dagger}, EDWARD F FITZGERALD{dagger} and HERBERT I JACOBSON{ddagger}

*Department of Epidemiology and Public Health, Yale University School of Medicine New Haven, CT 06510, USA.
**Department of Applied Medical Sciences, University of Southern Maine Portland, ME, USA.
{dagger}New York State Department of Health Albany, NY, USA.
{ddagger}Section of Reproductive Studies, Albany Medical College Albany, NY, USA

Janerich DT (Department of Epidemiology and Public Health, Yale University, School of Medicine, New Haven, CT06510, USA), Mayne ST, Thompson WD, Stark AD, Fitzgerald EF, Jacobson HI. Familial clustering of neural tube defects and gastric cancer. International Journal of Epidemiology 1990, 19: 516–521.

A retrospective cohort study was conducted to determine whether producing an offspring with a neural tube defect (NTD) is associated with the development of unusual patterns of cancer among the parents in subsequent years. Mothers and fathers who had a child with an NTD in Upstate New York from 1945 to 1955 were followed through 1979 and compared to a control group of parents with normal offspring. Overall mortality and site-specific cancer incidence were not significantly different for case parents versus control parents, with the exception of gastric cancer, which occured significantly more frequently in case parents. The finding of a familial association between NTDs and gastric cancer, coupled with a parallel decline in rates of these two diseases, suggests a common aetiology, perhaps related to dietary factors.

Revised 1 December 1989


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