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© 1990 Oxford University Press

research-article

Blood Cadmium in London Civil Servants

J STAESSEN*,, W B YEOMAN**, A E FLETCHER*, H L J MARKOWE{dagger}, M G MARMOT{dagger}, G ROSE{ddagger}, A SEMMENCE$, M J SHIPLEY{ddagger} and C J BULPITT*

*Epidemiology Research Unit, Division of Geriatric Medicine, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital London W12 0HS, UK.
**The Regional Laboratory for Toxicology, Dudley Road Hospital Birmingham B18 7QH, UK
{dagger}Department of Community Medicine, University College and Middlesex School of Medicine 66–72 Gower Street, London WC1E 6EA, UK.
{ddagger}Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine Keppel Street, London WC1E 7HT, UK.

Reprint requests to: DiJ. Staessen, KJinisch Laboratorium Hypertertsie, UZ Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

Staessen J (Epidemiology Research Unit, Division of Geriatric Medicine, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 OHS, UK), Yeoman W B, Fletcher A E, Markowe H L J, Marmot M G, Rose G, Semmence A, Shipley M J and Bulpitt C J. Blood cadmium in London civil servants. International Journal of Epidemiology 1990, 19: 362–366.

Blood cadmium was measured in 466 randomly selected London civil servants not exposed to heavy metals at work. Blood cadmium ranged from 3.6 to 75.6 nmol/L (0.4 to 8.5µ g/L) with a geometric mean of 6.4 nmol/L (0.7 µg/L) in non-smokers and 13.6 nmol/L (1.5 µg/L) in smokers (p<0.001). Blood cadmium was higher in women than in men (9.5 versus 7.8 nmol/L) and was inversely correlated with employment grade (p<0.001). The associations with age, body weight and alcohol intake were not significant. After adjusting for gender and the number of cigarettes smoked per day, 36% of the variance of blood cadmium was explained, while the contribution of employment grade was not significant.

There was an unexpected negative relationship between serum creatinine and blood cadmium in men (r = –0.16; p<0.01). This was not true in women (r= +0.03), but the correlation remained present in men after adjustment for age, body mass index and smoking. In contrast, in the two sexes, the correlations between blood pressure and blood cadmium were weak and not statistically significant.

In conclusion, in unexposed subjects, gender and smoking are important determinants of blood cadmium. In addition, a low level of environmental exposure to cadmium is not associated with a deterioration of renal function or an increase in blood presssure.

Received 1 June 1989


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