Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (39)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by LA VECCHIA, C.
Right arrow Articles by FRANCESCHI, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LA VECCHIA, C.
Right arrow Articles by FRANCESCHI, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 Oxford University Press

research-article

Occupation and the Risk of Bladder Cancer

CARLO LA VECCHIA*,**, EVA NEGRI*,{dagger}, BARBARA D'AVANZO* and SILVIA FRANCESCHI{ddagger}

*‘Mario Negri’ Institute for Pharmacological Research Via Eritrea 62, 20157 Milan, Italy.
**Institute of Social and Preventive Medicine Lausanne, 1005 Lausanne, Switzerland.
{dagger}Inter-University Consortium of Lombardy for Automatic Data Processing (CILEA) 20090 Segrate, Milan, Italy.
{ddagger}Aviano Cancer Center 33081 Aviano, Pordenone, Italy.

La Vecchia C (Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy), Negri E, D'Avanzo B and Franceschi S. Occupation and the risk of bladder cancer. International Journal of Epidemiology 1990; 19: 264–268.

The relationship between bladder cancer, occupation and exposure to a number of occupational agents was assessed in a case-control study conducted in the greater Milan area, Northern Italy. The case series consisted of 263 cases (219 males, 44 females) with histologically confirmed invasive bladder cancer, admitted to a network including major teaching and general hospitals in the area under surveillance. The controls were 287 patients (210 males, 77 females), admitted for acute, non-neoplastic or urinary tract diseases to the same network of hospitals. Cases more frequently reported occupation in dyestuff production (relative risk (RR) = 4.6), painting/spraying work (RR = 1.8), chemicalindustry (RR = 1.7), pharmaceuticals (RR = 1.7) and coal/gas production (RR = 3.1). Only for dyestuff production however, was the excess statistically significant. There was no association with agriculture or related activities, rubber manufacturing, printing, the petroleum industry, food processing and mechanics. In relation to exposure to occupational agents, significant positive trends in risk were observed for dyes/paints (RR = 4.8 for > ten years of exposure), herbicides (RR = 4.1), chemicals (RR = 2.4) and gases/fumes (RR = 4.8). No association was found with metals or metal dusts, plastic resins or glues, oil, wood dust, solvents or benzene, asbestos, electricity or radar and coal tar. Besides confirming the well known association between bladder cancer risk and dyestuff production and, to a lesser extent, a wide spectrum of chemical-related activities, this study provides statistically significant evidence of an independent role of herbicides on the risk of bladder cancer. Some of the negative results, such as the absence of association with printing, furniture manufacturing, plastic resins or glues and mechanics (whose 90% upper confidence limit was 1.4) are of interest, too, and probably indicate that these occupations are not per se strongly related with bladder cancer risk, although contamination with bladder carcinogens may occur in specific situations, and hence explain the elevated risk found in other studies.

Revised 1 August 1989


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
L. S. Engel, E. Taioli, R. Pfeiffer, M. Garcia-Closas, P. M. Marcus, Q. Lan, P. Boffetta, P. Vineis, H. Autrup, D. A. Bell, et al.
Pooled Analysis and Meta-analysis of Glutathione S-Transferase M1 and Bladder Cancer: A HuGE Review
Am. J. Epidemiol., July 15, 2002; 156(2): 95 - 109.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.